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what is a glp-1 antagonist GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys: Cell Reports Medicine

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GLP 1 drugs may be doing more than managing diabetes and weight. New data suggests they could also lower the risk of substance use disorders. These drugs affect appetite and reward pathways in the Mounjaro Tirzepatide Glp 1 Gip Receptor Agonist Stok Fotoraf 2453657649 Shutterstock Have you hit a weight loss stall on GLP 1 therapy? At Dupre Medical Clinic, we understand how frustrating it can be when the scale stops movingeven with consistent effort and Most viewed this week from JAMA: In patients with cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization for heart failure or all cause mortality vs sitagliptin, but tirzepatide offered no
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Susan Cedar
Belleville, US
★★★★★ 4
My dog loves glowing fetch at night!
Style: Glow Balls (Pack of 3), Size: 2.5 inch
Fantastic. Sturdy. My dog loves them Glow in the dark is great for fetch at night. I keep a flashlight with me because the glow doesn't last really long. But they charge very quickly and are really bright.
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Reviewed in the United States on February 22, 2026
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Maddox
Lexington, US
★★★★★ 5
Indestructible
Style: Fetch Balls (Pack of 2), Size: 3 inch
These balls are indestructible! We have a lab and a lab mix and they CANNOT damage these balls. They love them for fetch and to just chew on them (slightly squishy, but NO damage). Best toys we have bought for them.
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Reviewed in the United States on April 19, 2026
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Animal Lover
Whiting, US
★★★★★ 5
Great trial set. Just be careful throwing the orange one!
Style: Assorted Balls (Pack of 3), Size: 2.5 inch
Blue isn't that easy to see in the yard White charges with bright light/UV and is truly a game changer for night-time fetch. Both dogs clearly favor it. Orange is easy to see in the grass at day They're 3 different weights as well, so double trial. I prefer medium for my big dogs, though light performs well too The orange is HEAVY and unyielding. Do NOT throw it with a ball thrower. It could damage your house or knock your dog out. Seems tough though.
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Reviewed in the United States on January 16, 2026
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Verified Purchase
Spo509
Whiting, US
★★★★★ 3
Not as good as chuck it anymore
Style: Fetch Balls (Pack of 10), Size: 2.5 inch
I have bought these before and the where just like the chuck it balls. These are not those balls. The are lighter and my dog has already cause damage to one
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Reviewed in the United States on March 16, 2026
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Jessica Williams
Cuba, US
★★★★★ 5
Boredom Buster
Color: Green
This ball has been a boredom buster lifesaver. On the first day my 15 week golden retriever puppy played with it for a good 2 hours straight. I was nervous he would immediately get bored with it but nope, he searches for it every day. It has helped with his puppy teething, he's more likely to play with this ball than come up and use my hand/arm/clothes to teethe on. The battery lasts a good amount of time and is quick to charge but I did wish it lasted a bit longer. Overall I'm very happy. We live in a top floor apartment but the noise doesn't seem to be too bad for the neighbors. It's good quality and seems durable. Edit: The velcro for the sleeve wears out within a couple uses. It keeps falling off. It was my puppies FAV thing about the toy because of the pull tag thing. So now it's ineffective for him. Not sure if there's a way to get a new sleeve or not.
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Reviewed in the United States on April 2, 2025

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