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Semaglutide and tirzepatide are both GLP 1 medications but they're not the same. Semaglutide works on one hormone (GLP 1) to reduce appetite and slow digestion. Tirzepatide works on two hormones ( Semaglutide Description, Uses, & Side Effects Britannica Woman shares journey of weight loss and gain after using semaglutide Semaglutide vs Tirzepatide, same medication class, different receptor targets. Here's what that actually means. Semaglutide targets the GLP 1 receptor, found in the brain, gut, and pancreas. Tirzepatide targets two: GLP 1 and GIP.
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