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Once-weekly retatrutide significantly reduced body weight and improved knee pain and physical function in adults with obesity and osteoarthritis in a phase 3 trial. Read more with the links in the comments
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The side effect concern with retatrutide is a condition called dysesthesia. It's an abnormal skin sensation. Tingling, numbness, or pain in the skin. In the trial, 12.5% of patients on the highest
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